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End-organ disease was reported in 4 seronegative recipients of valacyclovir (2 had pneumonitis, imuran azatioprina para que sirve 1 had gastroenteritis, and 1 had hepatitis) and 27 seronegative recipients of placebo (7 had pneumonitis, 6 had gastroenteritis, 19 had hepatitis, 6 had nephropathy, and 2 had other manifestations; some patients had more than one manifestation). They recommend one of two basic approaches: episodic therapy (that is, taking the medicine whenever you experience an outbreak) or suppressive therapy (taking the medicine daily to minimize the chances of recurrent or future outbreaks)? Prednisone or hydrocortisone is used most commonly.

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